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                          April 28, 2022

       Paula Ragan, Ph.D.
       Chief Executive Officer
       X4 Pharmaceuticals, Inc
       61 North Beacon Street, 4th Floor
       Boston, Massachusetts 02134

                                                        Re: X4 Pharmaceuticals,
Inc
                                                            Registration
Statement on Form S-3
                                                            Filed April 22,
2022
                                                            File No. 333-264459

       Dear Dr. Ragan:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Tyler
Howes at 202-551-3370 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Courtney Thorne, Esq.